The purpose of molecular pathology is to elucidate the mechanisms of disease by identifying alterations in molecular and pathway. At the core of this still-evolving discipline is the application of classical and novel techniques developed in cell biology, molecular biology, biochemistry, proteomics and genetics, to the evaluation of pathological processes. In drug discovery and preclinical safety assessment, morphological changes in cells are often accompanied by changes in DNA, RNA, or protein molecules. Further understanding of these molecular changes can help to understand target distribution, pharmacodynamics, and to elucidate pharmacological and/or toxicological mechanisms. In addition, there is an increasing demand for information on tumor sub-classification, prognosis, therapeutic response, and molecular therapeutic targets. These demands are increasingly covered by molecular pathology and require an extended spectrum of methods. Many of these molecular pathology methods rely on the use of labeled antibodies and nucleic acid probes, either based on slide or fluid. These methods include polymerase chain reaction (PCR), DNA and RNA sequencing, flurorescence in situ hybridization (FISH) and gene array assays.
Creative Bioarray offers state-of-the-art molecular pathology services on multiple high-throughput test platforms, including DNA, RNA and protein preparation from a large number of samples for molecular assays, massive parallel sequencing, Sanger sequencing, gene expression analysis and quantitative PCR.
- In situ hybridization (ISH)
- PCR and quantitative PCR
- Chromosome analysis
- DNA microarrays
- Next generation sequencing (NGS) services
Our team combines a long history in molecular biology and histopathology to relate gene expression to histomorphology in both normal tissues and therapeutic disease models to provide you with valuable functional genomics information. In addition, they are well versed in histopathological and immunocytochemical methods, providing all-inclusive services in sample preparation, imaging and image analysis, as well as consultation for ongoing or future research projects.