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Musculoskeletal Pathology Services

Musculoskeletal diseases include more than 150 confirmed conditions that affect the motor system. They range from short-lived problems (such as fractures, sprains, and strains) to lifelong conditions such as persistent pain and disability. The typical characteristics of musculoskeletal disorders are pain (usually persistent pain) and limited mobility and function.

Musculoskeletal diseases include the following diseases:

  • Joint problems, such as osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, and ankylosing spondylitis.
  • Bone problems, such as osteoporosis, osteopenia, fragility fractures, traumatic fractures.
  • Muscle problems, such as sarcopenia.
  • Spinal problems, such as back and neck pain.
  • Problems in multiple parts of the body or system, such as localized and widespread pain and inflammatory diseases of musculoskeletal.

Creative Bioarray have an experienced pathology research team and advanced technology platform. Histological methods play an important role in discovering the characteristics of muscle and bone tissue, assessing disease development, and observing the healing of fractures and bone defects. We provide comprehensive services based on bone and muscle histopathology to support your research.

Bone histomorphometry can be divided in static and dynamic histomorphometry. The static histomorphometry describes the quantitative assessment of bone structure, as well as bone cells in remodeling and modeling. It provides information that is not available from other investigative approaches, for example, bone densitometry and biochemical markers of bone turnover, and enables a more precise characterization of disease states and their response to treatment than can be obtained from qualitative examination of bone histology. Bone histomorphometry has been particularly valuable in determining the cellular pathophysiology of different forms of bone diseases and in defining the mechanisms by which drugs affect bone. In addition, it plays a central role in establishing the bone safety of drugs in humans. It can be applied either to bone histological sections or to high-resolution images produced by techniques such as microcomputed tomography and micromagnetic resonance imaging.

The dynamic histomorphometry describes the rate of bone formation during a period of time. The undecalcified bone labeled with calcein and alizarin red double labeling was used for the histomorphometric evaluation of bone dynamics, including mineralizing surface, mineral apposition rate, and bone formation rate. The dynamic histomorphometry can reflect the activity of osteoblasts on bone surface during bone remodeling.

  • Dynamic bone formation variables
  • Cancellous and cortical bone structural analyses
  • Bone cells variables
  • Defect or implant site healing

Muscle histomorphometry

Skeletal muscle is composed of muscle cells, fat cells, fibroblasts and other cell types. Multinucleated muscle cells are the main component of skeletal muscle and are also called muscle fibers (muscle fibers). Muscle histology research is a conventional method to study muscle function. Muscle function is determined by its structure and fiber type composition. According to different metabolic characteristics and the expression of myosin heavy chain (MyHC) subtypes, muscle fibers are divided into four types (I, IIa, IIx and IIb). Analysis of muscle fiber composition helps to study muscle metabolism and contraction function.

  • Myofiber density and number
  • Myofiber typing

We provide different processing methods for different research requirements. Please contact us for more detail information.

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