Product ID: HVA17
Antibodies
| OVERVIEW | |
|---|---|
| Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. | |
| Product Details | |
| Application | IF; IHC; WB |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol. |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/ml |
| Conjugation | HRP |
| Host Species | Mouse |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 91-381 of human CK8 (NP_002264) produced in E.coli. |
| Isotype | IgG2b |
| NCBI Accession Number | NP_002264 |
| Predicted Protein Size | 53.5 kDa |
| Protein Families | Druggable Genome |
| Purification | Affinity purification |
| Recommended Dilution | WB 1:2500~5000; IHC 1:50~150; IF 1:50~1:100 |
| Shipping | Shipping with blue ice. |
| Synonyms | CARD2; CK-8; CK8; CYK8; K2C8; K8; KO |
| Target Species | Dog; Human; Monkey; Mouse; Rat |
| UniProt ID | P05787 |
| Storage | Stored at -20°C for 1 year |
| LIMITATIONS | |
| All products are for research use only. | |
